• br Benefits and risks of traditional combined oestrogen prog

  2019-09-23

  

  Benefits and risks of traditional combined oestrogen–progestogen HRT regimens Combined oestrogen–progestogen regimens were developed to reproduce the short- and long-term benefits of oestrogen replacement therapy (ERT) and to simultaneously provide appropriate protection against oestrogen-related

• br Results br Discussion In

  2019-09-23

  

  Results Discussion In this study, we investigated the role of EP4 on invasion and invadopodia in breast cancer cells. Our results demonstrate that EP4 activation promotes invadopodia-driven ECM degradation, in turn facilitating future intravasation and metastasis of breast cancer fluvastatin

• Diagnosis of NCC can be accomplished

  2019-09-23

  

  Diagnosis of NCC can be accomplished via imaging techniques and serological confirmatory testing. The best immunodiagnostic test for NCC, the enzyme-linked immunotransfer blot EITB (Tsang et al., 1989), is based on the detection of XMD8-92 to one or more of the 7 lentil-lectin glycoproteins (LLGP)

• br Conflicts of interest br Introduction Arylamine N

  2019-09-23

  

  Conflicts of interest Introduction Arylamine N-acetyltransferase 1 (NAT1, EC 2.3.1.5) is a cytosolic enzyme that catalyses the acetylation of small molecule arylamines, hydrazines and sulphonamides (Hein, 2002). Found in most APY29 in the body, NAT1 expression is regulated at the transcriptio

• The present study found a significant negative correlation

  2019-09-23

  

  The present study found a significant negative correlation between miR-152-3p and CDK8 expression in human HCC tissues. We also validated that CDK8 was a direct target of miR-152-3p, and overexpression of miR-152-3p inhibited proliferation and induced apoptosis in HCC further info by suppressing CD

• br Transparency document br Results and Discussion br Experi

  2019-09-23

  

  Transparency document Results and Discussion Experimental Procedures Acknowledgments The casein kinase 1 (CK1) family consists of at least seven different gene products, often referred to as isoforms (α, β, γ1, γ2, γ3, δ, ε, with splice forms described for CK1α, γ, and ε (reviewed in )

• Introduction Piperine is a pungent alkaloid and

  2019-09-23

  

  Introduction Piperine is a pungent alkaloid and accounts for 2–5% dry weight in black and white peppers (Butt et al., 2013). Physiological benefits of piperine have been a subject of extensive research in recent years. Piperine is an antioxidant with strong anti-inflammatory and antiangiogenic acti

• The mitogen activated protein kinase MAPK family which consi

  2019-09-23

  

  The mitogen-activated protein kinase (MAPK) family, which consists of extracellular signal-regulated protein kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun N-terminal kinase (JNK), is involved in the development of NP (Hung et al., 2012, Ji et al., 2009). Recently, Zhuang et al. (2005) demonstrated that t

• br Molecular genetics Based on the genetic mutations associa

  2019-09-23

  

  Molecular genetics Based on the genetic mutations associated with their development, sarcomas are subdivided into two distinct classes. One class is composed of tumors bearing complex karyotypic abnormalities with no particular pattern. The second class, which includes Ewing sarcoma, encompasses

• br Disclosure statement br Acknowledgements This research

  2019-09-23

  

  Disclosure statement Acknowledgements This research was supported by grants from the National Institutes of Health, NS046400 and AG022971 (SD), and a fellowship from the Korea Research Foundation, KRF-2007-357-E00016 (YTK). The authors thank Dr. Barbara Crain for assistance with the immunologi

• br Materials and methods br

  2019-09-23

  

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th

• This article is based on previous research work in

  2019-09-21

  

  This article is based on previous research work [43] in the field of distributed development of information systems [34]. In that work, the system infrastructure focusing on the three-level data model used in the different layers of our architecture is described. The work presented in this manuscrip

• br Acknowledgements br Introduction Water and electrolytes c

  2019-09-21

  

  Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and idarubicin kinase governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in cance

• br Experimental Procedures br Author Contributions br Acknow

  2019-09-21

  

  Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s

• MoAbs targeting the tumourigenic pathways such as IGF R may

  2019-09-21

  

  MoAbs targeting the tumourigenic pathways, such as IGF-1R may theoretically have a dual working mechanism. On the one hand they block pathways having an anti-tumour working mechanism, and on the other hand they may also stimulate an immunological response inducing a reaction of the patients own immu

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