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During recent years two primary types of models
2020-01-15

During recent years, two primary types of models have been applied for calculating various thermodynamic properties of amino 7915 solutions, i.e. excess Gibbs energy (gE) models used numerously to describe the solubility of amino acid solutions, and equations of state (EOS) models appropriate to ob
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br Methods br Results br Discussion Literature showed SN
2020-01-15

Methods Results Discussion Literature showed SN was well studied for its antigastric ulcer, antiinflammatory, antihyperglycemic, and antihyperlipidemic properties. Although a recent publication reported that SN was found to exert its regulatory effect in animal cholesterol levels, the exact
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Early studies from the mollusk Aplysia reported the presence
2020-01-15

Early studies from the mollusk, Aplysia, reported the presence of a unique class of Berberine hydrochloride australia receptors in neurons, the acetylcholine-gated chloride channels (ACCs) (Kehoe and McIntosh, 1998). Later, studies identified these receptors in the model nematode Caenorhabditis eleg
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We consider the following perturbation of problem
2020-01-15

We consider the following perturbation of problem (2):where ∊>0 is an identity element. For a given ∊, we solve problem (3) to get the solution (x, y, λ). As ∊ decreases slowly toward 0, the optimum of F follows to the global optimum of F0. This set of constraint conditions is called the central pat
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In this study we implicate SCFFBXO E ligase as a
2020-01-14

In this study, we implicate SCFFBXO3 E3 ligase as a critical modulator of inflammation in atherosclerosis and demonstrate the efficacy of a small molecule FBXO3 inhibitor in suppressing inflammatory responses important in atherosclerosis. Specifically, individuals carrying a hypofunctioning genetic
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Targeting a specific cell type rather than the broad
2020-01-14

Targeting a specific cell type, rather than the broad cytotoxicity exhibited by some of the pharmacological agents currently used to treat lupus, may improve efficacy and decrease off target toxicity. Thus, evidence that macrophages and microglia are important to the pathogenesis of LN and NPSLE, re
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br Materials and methods br Results
2020-01-14

Materials and methods Results The i.v. administration of urocortin 2 reduced the mean arterial blood pressure in a dose-dependent manner (Fig. 1). The ED50 for the urocortin 2 cumulative dose–response effect on mean arterial blood pressure was 0.014±0.004 mg kg−1. Urocortin 2 administration ha
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Other enzymes outside of the circadian clock also
2020-01-14

Other Clozapine outside of the circadian clock also have effects on CR. Lithium, a drug used to treat bipolar disorder, has been shown to lengthen τ in a variety of systems [17]. While the molecular mechanism whereby lithium exerts its therapeutic effect is unclear, it is known to be an inhibitor o
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There was a good alignment
2020-01-13

There was a good alignment profile between compound 26 (IC50 0.06μM) and MTX (IC50 0.08μM) explaining its activity pattern (Fig. 5a). Fig. 5b clearly indicates a different alignment profiles where carbonyl groups are not on the same side between 25 (IC50>100.0μM) and MTX which is in consistency with
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The intricate roles and neural systems and mechanisms involv
2020-01-13

The intricate roles and neural systems and mechanisms involved in the CRF1 and CRF2 mediation of spontaneous and stress-induced anxiety behavior remain to be defined. Of particular relevance are studies evaluating the behavioral actions of CRF1 and CRF2 receptors separately as well as together. For
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It is common for plants
2020-01-13

It is common for plants that are deficient in P to invest in their roots in order to maximise P uptake from the soil. Here, plants grown in soil amended with OA had a higher root biomass:shoot Halopemide ratio compared with plants in the INORG-P treatment. Additionally, greater allocation of C to r
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Introduction Hepatocarcinoma is a common and aggressive form
2020-01-13

Introduction Hepatocarcinoma is a common and aggressive form of cancer (Trad et al., 2017). Due to a high rate of postoperative recurrence and metastasis, the prognosis for HCC remains dismal (Wang et al., 2017a, 2017b). Subclinical metastasis is the major cause responsible for tumor recurrence and
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br Author contributions br Funding M E B
2020-01-13

Author contributions Funding M.E.B. was supported by Research Fund #3096. Competing interests Introduction Lung cancer has become one of the most common death causes in both male and female malignant tumors (Jemal et al., 2011). Air pollution, smoking and estrogen level are known risk f
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br Materials and methods br Results and discussion br
2020-01-13

Materials and methods Results and discussion Conclusions The fabrication and characterization of AMCs reinforced with SiC and RHA was done in this study. Following conclusions are drawn from the above study: Conflict of interest Authors\' contributions Introduction Industrialisati
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br Conflict of interest br Acknowledgements This work was
2020-01-13

Conflict of interest Acknowledgements This work was supported by the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (2013R1A1A1076117) and also by the Priority Research Centers Program through the NRF funde
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